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WNT11

wingless-type MMTV integration site family, member 11

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.

Gene Name: wingless-type MMTV integration site family, member 11
Family/Subfamily: WNT , not assigned-WNT
Synonyms: WNT11, HWNT11, Protein Wnt-11
Target Sequences: NM_004626 NP_004617.2 O96014

Publications (2)

1
WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer. Anna Kotrbová, Petra Ovesná, Tomáš Gybel', Tomasz Radaszkiewicz, Markéta Bednaríková, Jitka Hausnerová, Eva Jandáková, Luboš Minár, Igor Crha, Vít Weinberger, Ludek Záveský, Vítezslav Bryja, Vendula Pospíchalová. Theranostics. 2020 Jan;10:537-552. [Full Text Article] [PubMed:31903136] [PMC:PMC6929979] Related Antibodies: LS-C185754.
2
RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanárová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybel, Karol Kaiser, Lucia Demková, Lucia Kucerová, Tomáš Bárta, David Potešil, Zbynek Zdráhal, Karel Soucek, Vítezslav Bryja. eLife. 2021 October;10:e65759. [Full Text Article] [PubMed:34702444] [PMC:PMC8550759] Related Antibodies: LS-C185754.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).