WIBG

within bgcn homolog (Drosophila)

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

WIBG (10)

Publications

No (10)

Tag

6His, C-terminus (2)

GST (1)

His (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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WIBG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126224

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.5 kDa

Price:

100 µg/$494

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WIBG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108876

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.5 kDa

Price:

100 µg/$494

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Human WIBG Protein (Recombinant 6His, C-terminus) (Met1-Leu204) - LS-G140317

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

23.7 kDa

Price:

10 µg/$344; 50 µg/$584

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Human WIBG Protein (Recombinant GST) (Full Length) - LS-G35729

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human WIBG Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68709

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.5 kDa

Price:

20 µg/$1,107

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Human WIBG Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68708

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.5 kDa

Price:

20 µg/$1,107

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Human WIBG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82886

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.5 kDa

Price:

20 µg/$150

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Human WIBG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82887

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.5 kDa

Price:

20 µg/$150

Select

Human WIBG Protein (Recombinant His) - LS-G857

Source:

E. coli

Tag:

His

Price:

50 µg/$392; 250 µg/$872; 10 µg/$286; 20 µg/$348; 100 µg/$511; 500 µg/$1,355

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Human WIBG Protein (Recombinant 6His, C-terminus) (Met1-Leu204) - LS-G39557

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

23.7kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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