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WEE1B / WEE2
WEE1 homolog 2 (S. pombe)
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
| Gene Name: | WEE1 homolog 2 (S. pombe) |
| Family/Subfamily: | Protein Kinase , Wee1/Mik1 |
| Synonyms: | WEE2, WEE1 homolog 2 (S. pombe), Wee1-like protein kinase 1B, WEE1B, Wee1-like protein kinase 2, Wee1B kinase |
| Target Sequences: | SK545D SK545P P0C1S8 |
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