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WEE1B / WEE2

WEE1 homolog 2 (S. pombe)

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.

Gene Name: WEE1 homolog 2 (S. pombe)
Family/Subfamily: Protein Kinase , Wee1/Mik1
Synonyms: WEE2, WEE1 homolog 2 (S. pombe), Wee1-like protein kinase 1B, WEE1B, Wee1-like protein kinase 2, Wee1B kinase
Target Sequences: SK545D SK545P P0C1S8

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Products
Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
WEE1B / WEE2 (3)
No (3)
Myc-DDK (Flag) (3)
Human (2)
293T Cells (1)
HEK 293 Cells (2)
WEE1B / WEE2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
62.7 kDa
20 µg/$150
WEE1B / WEE2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
62.7 kDa
100 µg/$494
WEE1B / WEE2 Protein - Purified recombinant protein WEE2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
62.7 kDa
20 µg/$1,107
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Products: Proteins


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).