order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
WEE1
WEE1 G2 checkpoint kinase
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
| Gene Name: | WEE1 G2 checkpoint kinase |
| Family/Subfamily: | Protein Kinase , Wee1/mik1 |
| Synonyms: | WEE1, Wee1 homolog, WEE1+ homolog, WEE1A, Wee1A kinase, WEE1hu, Wee1 tyrosine kinase, Wee1-like protein kinase, Wee1+ (S. pombe) homolog, WEE1 homolog (S. pombe) |
| Target Sequences: | NM_003390 NP_003381.1 P30291 |
Publications (1)
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
