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Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
Gene Name: | WDYHV motif containing 1 |
Synonyms: | WDYHV1, C8orf32, Nt(Q)-amidase, N-terminal Gln amidase, NTAQ1, WDYHV motif containing 1 |
Target Sequences: | NM_018024 NP_060494.1 Q96HA8 |
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