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WDR4
WD repeat domain 4
WDR4 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene.
| Gene Name: | WD repeat domain 4 |
| Synonyms: | WDR4, WD repeat-containing protein 4, TRMT82, TRM82, WD repeat domain 4 |
| Target Sequences: | NM_018669 CAB93145.1 P57081 |
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