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WDR35
WD repeat domain 35
WDR35 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.
| Gene Name: | WD repeat domain 35 |
| Synonyms: | WDR35, CED2, IFT121, KIAA1336, WD repeat domain 35, Naofen |
| Target Sequences: | AB037757 BAA92574.2 Q9P2L0 |
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