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WDR11 / BRWD2 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
Gene Name: | WD repeat domain 11 |
Synonyms: | WDR11, HH14, WD repeat domain 11, WD repeat domain 15, BRWD2, DR11, KIAA1351, WDR15 |
Target Sequences: | NM_018117 NP_060587.8 Q9BZH6 |
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