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WDPCP / FRITZ is a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants.
Gene Name: | WD repeat containing planar cell polarity effector |
Synonyms: | WDPCP, BBS15, C2orf86, FRITZ, FRTZ, HFrtz |
Target Sequences: | NM_015910 NP_056994.3 O95876 |
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