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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.
Gene Name: | tryptophanyl tRNA synthetase 2, mitochondrial |
Synonyms: | WARS2, Tryptophanyl-tRNA synthetase, TrpRS, Tryptophan-tRNA ligase |
Target Sequences: | NM_015836 NP_056651.1 Q9UGM6 |
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