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Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway.
Gene Name: | WW Domain Containing Adaptor With Coiled-coil |
Synonyms: | WAC, BM-016, KIAA1844, PRO1741, WWP4 |
Target Sequences: | NM_016628 NP_057712.2 Q9BTA9 |
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