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VTN / Vitronectin

vitronectin

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Gene Name:	vitronectin
Family/Subfamily:	Matrix Protein , not assigned-Other
Synonyms:	VTN, Epibolin, Serum-spreading factor, VNT, S-protein, Somatomedin B, V75, VN, Complement S-protein, Serum spreading factor, Vitronectin
Target Sequences:	NM_000638 NP_000629.3 P04004

Publications (4)

Structure of human Vitronectin C-terminal domain and interaction with Yersinia pestis outer membrane protein Ail. Shin K, Lechtenberg BC, Fujimoto LM, Yao Y, Bartra SS, Plano GV, Marassi FM. Science advances. 2019 September;5: [Full Text Article] [PubMed:31535027] [PMC:PMC6739113] Related Antibodies: LS-C407672.

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Jiasheng Zhang , Dmitry Velmeshev , Kei Hashimoto , Yu-Hsin Huang , Jeffrey W Hofmann, Xiaoyu Shi, Jiapei Chen, Andrew M Leidal, Julian G Dishart, Michelle K Cahill, Kevin W Kelley, Shane A Liddelow, William W Seeley, Bruce L Miller, Tobias C Walther, Robert V Farese Jr, J Paul Taylor, Erik M Ullian, Bo Huang, Jayanta Debnath, Torsten Wittmann, Arnold R Kriegstein, Eric J Huang. Nature. 2020 August; [Full Text Article] [PubMed:32866962] [PMC:PMC7746606]

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Yukitaka Ito, Sou Nakamura, Naoshi Sugimoto, Tomohiro Shigemori, Yoshikazu Kato, Mikiko Ohno, Shinya Sakuma, Keitaro Ito, Hiroki Kumon, Hidenori Hirose, Haruki Okamoto, Masayuki Nogawa, Mio Iwasaki, Shunsuke Kihara, Kosuke Fujio, Takuya Matsumoto, Natsumi Higashi, Kazuya Hashimoto, Akira Sawaguchi, Ken-Ichi Harimoto, Masato Nakagawa, Takuya Yamamoto, Makoto Handa, Naohide Watanabe, Eiichiro Nishi, Fumihito Arai, Satoshi Nishimura, Koji Eto. Cell. 2018 July;174:636-648.e18. [Full Text Article] [PubMed:30017246]

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex. Nicole Merritt , Keith Garcia , Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas. eLife. 2021 April;10:e62857. [Full Text Article] [PubMed:33913810] [PMC:PMC8143797] Related Antibodies: LS-B2118.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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