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VTI1A

vesicle transport through interaction with t-SNAREs 1A

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

Gene Name: vesicle transport through interaction with t-SNAREs 1A
Synonyms: VTI1A, SNARE Vti1a-beta protein, VTI1RP2, MVti1, Vti1-rp2
Target Sequences: Q5W0D7 Q96AJ9

Publications (1)

1
Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons. Melissa Plooster, Guendalina Rossi, Martilias S Farrell, Jessica C McAfee, Jessica L Bell, Michael Ye, Graham H Diering, Hyejung Won, Stephanie L Gupton, Patrick Brennwald. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021 November;41:9466-9481. [Full Text Article] [PubMed:34642214] [PMC:PMC8580139] Related Antibodies: LS-C160556.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).