VRK2

vaccinia related kinase 2

Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

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Products

Proteins (8)

Type

Over-Expression Lysate (6)

Recombinant (2)

Target

VRK2 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (5)

Source

293T Cells (3)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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VRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115402

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

100 µg/$494

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VRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125063

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

100 µg/$494

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VRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125064

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

100 µg/$494

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Human VRK2 Protein (Recombinant GST, N-terminus) (aa260-360) - LS-G60517

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human VRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79586

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$150

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Human VRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79587

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$150

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Human VRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79588

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$150

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Human VRK2 Protein (Recombinant GST) (Full Length) - LS-G30889

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.62 kDa

Price:

2 µg/$439

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