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Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Gene Name: | vaccinia related kinase 1 |
Family/Subfamily: | Protein Kinase , VRK |
Synonyms: | VRK1, 51PK, PCH1A, Vaccinia related kinase 1, Vaccinia-related kinase 1, PCH1 |
Target Sequences: | NM_003384 NP_003375.1 Q99986 |
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