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VR1 / TRPV1

transient receptor potential cation channel, subfamily V, member 1

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.

Gene Name: transient receptor potential cation channel, subfamily V, member 1
Family/Subfamily: Ion Channel , Calcium channel - TRP
Synonyms: TRPV1, Capsaicin receptor, OTRPC1, Vanilloid receptor subtype 1, Osm-9-like TRP channel 1, Vanilloid receptor 1, VR1
Target Sequences: NM_018727 NP_061197.4 Q8NER1

☰ Filters
Antibodies (49)
ELISA Kits (11)
Proteins (10)
Custom (3)
Over-Expression Lysate (8)
Primary (49)
Recombinant (2)
Sandwich (8)
VR1 / TRPV1 (70)
Human (43)
Mouse (26)
Rat (29)
Chicken (1)
Dog (1)
Guinea pig (2)
Primate (5)
IHC (18)
IHC-Fr (3)
IHC-P (8)
WB (29)
ELISA (11)
ICC (10)
IF (9)
IP (2)
Peptide-ELISA (1)
rabbit (44)
mouse (1)
chicken (1)
guinea pig (2)
rabbit-new zealand white (1)
Product Group
PathPlus Neuro (2)
IgG (16)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (48)
1A8 (1)
12 x 8-Well Microstrips (1)
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Unconjugated (29)
aa1-153 (8)
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aa105-115 (1)
aa124-153 (1)
aa531-541 (1)
aa608-621 (1)
aa817-838 (1)
No (70)
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GST, N-terminus (1)
His, N-terminus (1)
Myc-DDK (Flag) (8)
Human (6)
293T Cells (4)
E. coli (1)
HEK 293 Cells (4)
Wheat Germ Extract (1)
VR1 / TRPV1 Antibody - Anti-TRPV1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (Internal) Antibody
Guinea pig, Human
IHC, IHC-P
Unconjugated
50 µg/$460
VR1 / TRPV1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IHC, IHC-P
Unconjugated
100 µl/$460
VR1 / TRPV1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY488 Conjugated
0.1 ml/$416
VR1 / TRPV1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
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VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Primate, Human
ICC, IF, WB
Unconjugated
0.1 ml/$386
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VR1 / TRPV1 Rabbit anti-Rat Polyclonal (Biotin) Antibody
Mouse, Rat, Primate, Human
ICC, IF, WB
Biotin Conjugated
0.1 ml/$416
VR1 / TRPV1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$380
VR1 / TRPV1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
VR1 / TRPV1 Antibody - TRPV1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (aa124-153) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
VR1 / TRPV1 Antibody - TRPV1 monoclonal antibody (M02), clone 1A8. Western blot of TRPV1 expression in rat thymus.
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VR1 / TRPV1 Mouse anti-Human Monoclonal (1A8) Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µg/$423
VR1 / TRPV1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
VR1 / TRPV1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$730
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VR1 / TRPV1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, IHC, WB
Unconjugated
100 µg/$832
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (aa608-621) Antibody
Guinea pig, Human
IHC
Unconjugated
100 µl/$688
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VR1 / TRPV1 Rabbit anti-Mouse Polyclonal (aa531-541) Antibody
Mouse, Rat
IHC-Fr
Unconjugated
100 µl/$614
VR1 / TRPV1 Protein - Recombinant  Transient Receptor Potential Cation Channel Subfamily V, Member 1 By SDS-PAGE
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E. coli
His, N-terminus
20.4 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
VR1 / TRPV1 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using TRPV1 Antibody at dilution of 1:100
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VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
VR1 / TRPV1 Antibody - Immunohistochemistry of paraffin-embedde human colon tissue using TRPV1 antibody at dilution of 1:100
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VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$376
VR1 / TRPV1 Antibody - Western blot analysis of TRPV1 expression in HeLa (A); Raw264.7 (B); PC12 (C) whole cell lysates.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
VR1 / TRPV1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
VR1 / TRPV1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
VR1 / TRPV1 Antibody - Western blot analysis of extracts of various cell lines.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
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VR1 / TRPV1 Guinea pig anti-Rat Polyclonal (aa817-838) Antibody
Rat
IHC
Unconjugated
50 µl/$508
VR1 / TRPV1 Antibody - Western Blot; Sample: Recombinant TRPV1, Human.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (aa1-153) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
VR1 / TRPV1 Antibody - Western blot of VR1 / TRPV1 antibody using recombinant TRPV1.
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VR1 / TRPV1 Rabbit anti-Human Polyclonal (aa1-153) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
Viewing 1-25 of 70 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).