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VPS36
vacuolar protein sorting 36 homolog (S. cerevisiae)
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
| Gene Name: | vacuolar protein sorting 36 homolog (S. cerevisiae) |
| Synonyms: | VPS36, CGI-145, ELL-associated protein, 45 kDa, ESCRT-II complex subunit VPS36, C13orf9, EAP45 |
| Target Sequences: | NM_016075 NP_057159.2 Q86VN1 |
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