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VPS26A / VPS26
vacuolar protein sorting 26 homolog A (S. pombe)
VPS26A / VPS26 belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | vacuolar protein sorting 26 homolog A (S. pombe) |
| Synonyms: | VPS26A, HB58, HVPS26, Hbeta58, PEP8A, Vesicle protein sorting 26A, VPS26 |
| Target Sequences: | NM_004896 NP_004887.2 O75436 |
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