VIPERIN / RSAD2

radical S-adenosyl methionine domain containing 2

Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

VIPERIN / RSAD2 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human VIPERIN / RSAD2 Protein (Recombinant GST) (Full Length) - LS-G36019

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.6 kDa

Price:

2 µg/$439

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Human VIPERIN / RSAD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67646

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$1,107

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Human VIPERIN / RSAD2 Protein (Recombinant GST, N-terminus) (aa262-361) - LS-G63474

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human VIPERIN / RSAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80373

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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VIPERIN / RSAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102208

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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