VIL1 / Villin

villin 1

Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

VIL1 / Villin (8)

Publications

No (8)

Tag

GST (2)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (3)

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VIL1 / Villin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114837

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.5 kDa

Price:

100 µg/$710

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Human VIL1 / Villin Protein (Recombinant GST, N-terminus) (aa1-77) - LS-G60510

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human VIL1 / Villin Protein (Recombinant GST) (Full Length) - LS-G30877

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73 kDa

Price:

10 µg/$479; 25 µg/$670

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Human VIL1 / Villin Protein (Recombinant GST) (Full Length) - LS-G30879

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.83 kDa

Price:

10 µg/$479; 25 µg/$670

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Human VIL1 / Villin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67325

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.5 kDa

Price:

20 µg/$1,107

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Human VIL1 / Villin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79549

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.5 kDa

Price:

20 µg/$215

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Human VIL1 / Villin Protein (Recombinant His, N-Terminal) (Thr2-Leu421) - LS-G96926

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

48 kDa

Price:

10 µg/$265; 100 µg/$365; 50 µg/$315

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Human VIL1 / Villin Protein (Recombinant His-T7) (aa1-320) - LS-G14997

Source:

E. coli

Tag:

His-T7

Molecular Weight:

39.6 kDa

Price:

50 µg/$412; 10 µg/$276; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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