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VEGFB is a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
|Gene Name:||vascular endothelial growth factor B|
|Family/Subfamily:||PDGF , not assigned-PDGF|
|Synonyms:||VEGFB, VRF, VEGF-B, VEGF-related factor, VEGFL|
|Target Sequences:||NM_003377 NP_003368.1 P49765|
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