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Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Gene Name: | voltage-dependent anion channel 2 |
Family/Subfamily: | Ion Channel , VDAC porin |
Synonyms: | VDAC2, B-36 vdac, HVDAC2, Porin-2, VDAC-2, Vdac6 |
Target Sequences: | NM_003375 NP_003366.2 P45880 |
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