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VCX3A belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit.
Gene Name: | variable charge, X-linked 3A |
Synonyms: | VCX3A, Variable charge, X-linked 3, Variably charged X-A, VCXA, Variable charge, X-linked 3A, Variably charged protein X-A, VCX-8r, VCX-A, VCX8R, VCX3 |
Target Sequences: | NM_016379 NP_057463.2 |
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