USP8 / UBPY

ubiquitin specific peptidase 8

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

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Proteins (10)

Type

Over-Expression Lysate (6)

Recombinant (4)

Target

USP8 / UBPY (10)

Publications

No (10)

Tag

His-T7 (1)

Myc-DDK (Flag) (9)

Species

Human (7)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (6)

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USP8 / UBPY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124819

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

100 µg/$710

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USP8 / UBPY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124821

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

100 µg/$710

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USP8 / UBPY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116157

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

100 µg/$710

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Human USP8 / UBPY Protein (Recombinant His-T7) (aa777-1118) - LS-G25558

Source:

E. coli

Tag:

His-T7

Molecular Weight:

43.3 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human USP8 / UBPY Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66653

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

20 µg/$1,107

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Human USP8 / UBPY Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66654

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

20 µg/$1,107

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Human USP8 / UBPY Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66655

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

20 µg/$1,107

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Human USP8 / UBPY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78221

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

20 µg/$215

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Human USP8 / UBPY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78222

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

20 µg/$215

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Human USP8 / UBPY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78223

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

127.3 kDa

Price:

20 µg/$215

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