USP7 / HAUSP

ubiquitin specific peptidase 7 (herpes virus-associated)

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked Ubiquitin chains.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

USP7 / HAUSP (8)

Publications

No (8)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

GST, N-terminus (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human USP7 / HAUSP Protein (Recombinant) (Lys208-Glu560) - LS-G137948

Source:

Insect Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41 kDa

Price:

100 µg/$926

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Human USP7 / HAUSP Protein (Recombinant His-T7) (aa54-507) - LS-G24717

Source:

E. coli

Tag:

His-T7

Molecular Weight:

56.3 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human USP7 / HAUSP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66652

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.1 kDa

Price:

20 µg/$1,107

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Human USP7 / HAUSP Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa214-521) - LS-G56874

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human USP7 / HAUSP Protein (Recombinant His-GST) (Lys208-Glu560) - LS-G98009

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

68.8 kDa

Price:

100 µg/$661

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Human USP7 / HAUSP Protein (Recombinant GST, N-terminus) (aa13-110) - LS-G60620

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human USP7 / HAUSP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78219

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.1 kDa

Price:

20 µg/$215

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USP7 / HAUSP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100055

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.1 kDa

Price:

100 µg/$710

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