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Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Gene Name: | ubiquitin specific peptidase 5 (isopeptidase T) |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP5, Deubiquitinating enzyme 5, ISOT, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin isopeptidase T, Ubiquitin thioesterase 5 |
Target Sequences: | NM_003481 NP_003472.2 P45974 |
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