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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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USP5

ubiquitin specific peptidase 5 (isopeptidase T)

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Gene Name: ubiquitin specific peptidase 5 (isopeptidase T)
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP5, Deubiquitinating enzyme 5, ISOT, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin isopeptidase T, Ubiquitin thioesterase 5
Target Sequences: NM_003481 NP_003472.2 P45974

Publications (1)

1
Functional analysis of C-type lysozyme in penaeid shrimp. Kaizu A, Fagutao FF, Kondo H, Aoki T, Hirono I. The Journal of biological chemistry. 2011 286:44344-9. [PubMed:22069322] [PMC:PMC3247961]

Filtered By: None
Target
USP5 (31)
Reactivity
Human (28)
Mouse (2)
Rat (6)
Bovine (1)
Dog (4)
Horse (1)
Monkey (4)
Rabbit (1)
Xenopus (1)
Application
IHC (9)
IHC-P (7)
WB (25)
ELISA (16)
IF (3)
IP (4)
Host
rabbit (21)
mouse (9)
chicken (1)
Isotype
IgG (16)
IgG1 (4)
IgG1,k (1)
IgG2a (3)
IgG2a,k (1)
IgY (1)
Clonality
monoclonal mc (9)
polyclonal pc (22)
Clone
1340CT704.170.140 (1)
1A8 (1)
1F8 (1)
1F9 (1)
2C8 (1)
2E3 (1)
2F5 (1)
2H5 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (22)
Epitope
aa484-514 (8)
aa375-425 (2)
aa2-223 (1)
aa204-217 (1)
aa75-125 (1)
Publications
No (31)
Showing 1-25 of 31 results

USP5 Antibody (clone 2F5) LS-C115297
Mouse Monoclonal [clone 2F5] (IgG1) to Human USP5
Human
IF IHC IHC-P WB
Unconjugated
100µl  $335.00
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).

USP5 Antibody (clone 2H5) LS-C115298
Mouse Monoclonal [clone 2H5] (IgG2a) to Human USP5
Dog, Rat, Human, Monkey
IHC IHC-P WB
Unconjugated
100µl  $335.00
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).

USP5 Antibody (clone 2E3) LS-C115299
Mouse Monoclonal [clone 2E3] (IgG2a) to Human USP5
Dog, Rat, Human, Monkey
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of paraffin-embedded Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).

USP5 Antibody (aa375-425) LS-C288345
Rabbit Polyclonal (IgG) to Human USP5
Human
IF IHC IHC-P IP
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human USP5/IsoT by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
Detection of Human USP5/IsoT by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

USP5 Antibody (clone 1F8) LS-C115296
Mouse Monoclonal [clone 1F8] (IgG2a) to Human USP5
Dog, Rat, Human, Monkey
IHC IHC-P WB
Unconjugated
100µl  $335.00
IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human thyroid tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Human thyroid tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).

USP5 Antibody (aa375-425) LS-C286553
Rabbit Polyclonal (IgG) to Human USP5
Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human USP5/IsoT by IHC-IF. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte Plus 555 (A120-501E) used at a dilution of 1:100.
Detection of Human USP5/IsoT by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:100.
Detection of Human USP5/IsoT by IHC-IF. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte Plus 555 (A120-501E) used at a dilution of 1:100.
Detection of Human USP5/IsoT by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:100.

USP5 Antibody (clone 1A8) LS-C115311
Mouse Monoclonal [clone 1A8] (IgG1) to Human USP5
IHC IHC-P WB
Unconjugated
100µl  $335.00
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).

USP5 Antibody (aa2-223) LS-C178920
Rabbit Polyclonal to Human USP5
Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $255.00
Immunohistochemistry Image
Western blot Image
Immunohistochemistry Image
Western blot Image

USP5 Antibody LS-C661506
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA IP WB
Unconjugated
100µg  $435.00

USP5 Antibody LS-C661507
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA IP WB
Unconjugated
100µg  $435.00

USP5 Antibody LS-C661202
Mouse Monoclonal (IgG1) to Human USP5
Human
ELISA WB
Unconjugated
100µg  $465.00

USP5 Antibody (clone 2C8) LS-C198526
Mouse Monoclonal [clone 2C8] (IgG2a,k) to Human USP5
Human
ELISA WB
Unconjugated
100µg  $355.00
Detection limit for recombinant GST tagged USP5 is approximately 0.03 ng/ml as a capture antibody.
Detection limit for recombinant GST tagged USP5 is approximately 0.03 ng/ml as a capture antibody.

USP5 Antibody (aa484-514) LS-C329045
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA WB
Unconjugated
200µl  $530.00

USP5 Antibody (aa484-514, Biotin) LS-C284101
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

USP5 Antibody (aa484-514, FITC) LS-C284102
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA WB
FITC Conjugated
200µl  $680.00

USP5 Antibody (aa484-514, APC) LS-C284100
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA WB
APC Conjugated
200µl  $680.00

USP5 Antibody (aa484-514, Azide-free, HRP) LS-C284103
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

USP5 Antibody (aa484-514, PE) LS-C284104
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA WB
PE Conjugated
200µl  $680.00

USP5 Antibody (aa484-514, AP) LS-C284098
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA WB
AP Conjugated
200µl  $680.00

USP5 Antibody LS-C86282
Rabbit Polyclonal to Rat USP5
Rat
IHC WB
Unconjugated
50µg  $415.00

USP5 Antibody (aa75-125) LS-C288334
Rabbit Polyclonal (IgG) to Human USP5
Xenopus, Rat, Horse, Rabbit, Mouse, Dog, Bovine, Human
IP WB
Unconjugated
100µl 0.2mg/ml  $395.00

USP5 Antibody (clone 1340CT704.170.140) LS-C344149
Mouse Monoclonal [clone 1340CT704.170.140] (IgG1,k) to Human USP5
Mouse, Rat, Human
WB
Unconjugated
400µl  $305.00
Western blot of lysates from U251, PC-3 cell line, mouse brain, rat brain and liver tissue lysates (from left to right) with USP5 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.
Western blot of lysates from U251, PC-3 cell line, mouse brain, rat brain and liver tissue lysates (from left to right) with USP5 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

USP5 Antibody (clone 1F9) LS-C337135
Mouse Monoclonal [clone 1F9] (IgG1) to Human USP5
Human, Monkey
WB
Unconjugated
100µl 0.82mg/ml  $335.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY USP5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-USP5.
Western blot of extracts (35ug) from 9 different cell lines by using anti-USP5 monoclonal antibody.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY USP5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-USP5.
Western blot of extracts (35ug) from 9 different cell lines by using anti-USP5 monoclonal antibody.

USP5 Antibody LS-C394791
Rabbit Polyclonal (IgG) to Human USP5
Human
ELISA
Unconjugated
50µg  $285.00; 100µg  $385.00

USP5 Antibody (aa484-514) LS-C99537
Rabbit Polyclonal to Human USP5
Human
WB
Unconjugated
400µl  $305.00
The anti-USP5 antibody is used in Western blot to detect USP5 in HL-60 cell lysate.
The anti-USP5 antibody is used in Western blot to detect USP5 in HL-60 cell lysate.
Showing 1-25 of 31 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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