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USP37
ubiquitin specific peptidase 37
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
| Gene Name: | ubiquitin specific peptidase 37 |
| Synonyms: | USP37, KIAA1594, Ubiquitin specific protease 37, Ubiquitin thiolesterase 37, Deubiquitinating enzyme 37, Tmp_locus_50, Ubiquitin thioesterase 37 |
| Target Sequences: | Q86T82 Q86T82 |
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