USP33 / VDU1

ubiquitin specific peptidase 33

Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

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Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

USP33 / VDU1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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USP33 / VDU1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113522

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.5 kDa

Price:

100 µg/$710

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Human USP33 / VDU1 Protein (Recombinant GST) (Full Length) - LS-G32709

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

129.7 kDa

Price:

2 µg/$439

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Human USP33 / VDU1 Protein (Recombinant GST, N-terminus) (aa327-426) - LS-G61903

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human USP33 / VDU1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68526

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.1 kDa

Price:

20 µg/$1,107

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Human USP33 / VDU1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82385

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.5 kDa

Price:

20 µg/$215

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Human USP33 / VDU1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82386

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.1 kDa

Price:

20 µg/$215

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USP33 / VDU1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103258

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.1 kDa

Price:

100 µg/$710

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