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USP30
ubiquitin specific peptidase 30
Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:24896179). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
| Gene Name: | ubiquitin specific peptidase 30 |
| Synonyms: | USP30, Ubiquitin thiolesterase 30, Ubiquitin specific protease 30, Deubiquitinating enzyme 30, Ub-specific protease 30, Ubiquitin thioesterase 30, Ubiquitin-specific protease 30 |
| Target Sequences: | NM_032663 AAH04868.1 Q70CQ3 |
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