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Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Gene Name: | ubiquitin specific peptidase 3 |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP3, Deubiquitinating enzyme 3, SIH003, Ubiquitin specific protease 3, UBP, Ubiquitin thiolesterase 3, Ubiquitin thioesterase 3, Ubiquitin specific peptidase 3 |
Target Sequences: | NM_006537 NP_006528.2 Q9Y6I4 |
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