USP28

ubiquitin specific peptidase 28

Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

USP28 (6)

Publications

No (6)

Tag

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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USP28 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110933

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.3 kDa

Price:

100 µg/$710

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Human USP28 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87487

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.3 kDa

Price:

20 µg/$215

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Human USP28 Protein (Recombinant DDK,C-terminus) - LS-G142481

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

122.3 kDa

Price:

20 µg/$677

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Human USP28 Protein (Recombinant GST) (Full Length) - LS-G34766

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

92.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human USP28 Protein (Recombinant GST, N-terminus) (aa978-1077) - LS-G62986

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human USP28 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70576

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.3 kDa

Price:

20 µg/$1,107

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