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Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.
Gene Name: | ubiquitin specific peptidase 28 |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP28, Deubiquitinating enzyme 28, KIAA1515, Ubiquitin specific protease 28, Ubiquitin thioesterase 28, Ubiquitin thiolesterase 28 |
Target Sequences: | NM_020886 NP_065937.1 Q96RU2 |
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