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Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
Gene Name: | ubiquitin specific peptidase 21 |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP21, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific protease 16, USP23, NEDD8-specific protease, Ubiquitin specific protease 21, Ubiquitin thiolesterase 21 |
Target Sequences: | NM_012475 CAH72142.1 Q9UK80 |
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