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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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USP2

ubiquitin specific peptidase 2

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.

Gene Name: ubiquitin specific peptidase 2
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP2, Deubiquitinating enzyme 2, Ubiquitin specific peptidase 2, Ubiquitin specific protease 9, USP9, Ubiquitin specific protease 12, Ubiquitin specific protease 2, Ubiquitin thioesterase 2, UBP41
Target Sequences: NM_004205 NP_004196.4 O75604

Publications (2)

1
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. The EMBO journal. 2007 26:976-86. [PubMed:17290220] [PMC:PMC1852834] Related Antibodies: LS-C99527.
2
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2. Oberfeld B, Ruffieux-Daidi D, Vitagliano JJ, Pos KM, Verrey F, Staub O. American journal of physiology. Renal physiology. 2011 301:F189-96. [PubMed:21478478] Related Antibodies: LS-C99529.

Filtered by: None
Target
USP2 (69)
Reactivity
Human (66)
Mouse (13)
Rat (18)
African green monkey (1)
Bovine (11)
Chimpanzee (6)
Dog (15)
Gibbon (3)
Guinea pig (3)
Hamster (7)
Horse (11)
Monkey (22)
Rabbit (11)
Application
IHC (49)
IHC-P (28)
WB (42)
ELISA (33)
IF (2)
Host
rabbit (68)
mouse (1)
Isotype
IgG (33)
IgG1,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (68)
Clone
1738CT331.50.87 (1)
Format
AP Conjugated (7)
APC Conjugated (6)
Azide-free (6)
Biotin Conjugated (9)
FITC Conjugated (9)
HRP Conjugated (9)
PE Conjugated (6)
Unconjugated (23)
Epitope
Internal (14)
aa380-410 (8)
aa508-538 (8)
aa71-101 (8)
C-Terminus (7)
aa371-420 (4)
aa71-120 (4)
Publications
No (67)
Yes (2)
Showing 1-25 of 69 results

IHC-plus™ USP2 Antibody (C-Terminus) LS-A8493
Rabbit Polyclonal to Human USP2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (C-Terminus, Biotin) LS-A107965
Rabbit Polyclonal to Human USP2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (C-Terminus, FITC) LS-A107966
Rabbit Polyclonal to Human USP2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (C-Terminus, APC) LS-A107964
Rabbit Polyclonal to Human USP2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (C-Terminus, AP) LS-A107963
Rabbit Polyclonal to Human USP2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (C-Terminus, PE) LS-A107968
Rabbit Polyclonal to Human USP2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (C-Terminus, Azide-free, HRP) LS-A107967
Rabbit Polyclonal to Human USP2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-USP2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (aa371-420) LS-B12742
Rabbit Polyclonal to Human USP2
Rabbit, Dog, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ USP2 Antibody (Internal) LS-A8743
Rabbit Polyclonal to Human USP2
Human
IHC, IHC-P
Unconjugated
50µg 55µl 0.9mg/ml  $425.00
Anti-USP2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

USP2 Antibody (aa508-538) LS-C99529
Publications (1)
Publications (1)
Rabbit Polyclonal to Human USP2
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Formalin-fixed and paraffin-embedded human testis tissue reacted with USP2 antibody (C-term L523), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

USP2 Antibody (aa71-101) LS-C99527
Publications (1)
Publications (1)
Rabbit Polyclonal to Human USP2
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
IHC for USP2a in a formalin-fixed, paraffin-embedded human prostate sample. Cytoplasmic positive immunostaining was detected in tumor glands (ii), whereas in normal prostatic epithelium, USP2a expression was restricted to the basal layer.
Western blot of lysate from R. heart cell line, using USP2 Antibody (T22). Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.

IHC-plus™ USP2 Antibody (Internal) LS-A8495
Rabbit Polyclonal to Human USP2
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 100µl 0.5mg/ml  $425.00
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (Internal, Biotin) LS-A107971
Rabbit Polyclonal to Human USP2
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (Internal, FITC) LS-A107972
Rabbit Polyclonal to Human USP2
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (Internal, AP) LS-A107969
Rabbit Polyclonal to Human USP2
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (Internal, APC) LS-A107970
Rabbit Polyclonal to Human USP2
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ USP2 Antibody (Internal, PE) LS-A107974
Rabbit Polyclonal to Human USP2
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-USP2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

USP2 Antibody LS-C679958
Rabbit Polyclonal (IgG) to Human USP2
Human
ELISA, IF, WB
Unconjugated
50µg 5mg/ml  $285.00; 100µg  $385.00
Immunofluorescent analysis of HepG2 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Western blot All Lanes :USP2 antibody at 2 ug/ml Lane 1 : Mouse liver tissue Lane 2 : Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 69,41,42,46 kDa Observed band size: 68 kDa

USP2 Antibody (aa380-410) LS-C99528
Rabbit Polyclonal to Human USP2
Human
WB
Unconjugated
400µl  $325.00
The anti-USP2 Antibody is used in Western blot to detect USP2 in USP2-transfected HeLa cell lysates. Transfection data is kindly provided by Dr. B. Pierrat from the Novartis Institute for Biomedical Research (Basel, Switzerland).
Western blot of anti-USP2 Antibody in HL60 cell line lysates (35 ug/lane). USP2(arrow) was detected using the purified antibody.

USP2 Antibody LS-C84166
Rabbit Polyclonal to Mouse USP2
Mouse
ELISA, IHC, WB
Unconjugated
100µg  $755.00

USP2 Antibody LS-C305926
Rabbit Polyclonal (IgG) to Human USP2
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100µg  $495.00
Western blot of USP2 antibody LS-X223178.

USP2 Antibody LS-C661488
Rabbit Polyclonal (IgG) to Human USP2
Human
ELISA, IHC, WB
Unconjugated
100µg  $435.00

USP2 Antibody LS-C661489
Rabbit Polyclonal (IgG) to Human USP2
Human
ELISA, IHC, WB
Unconjugated
100µg  $435.00

USP2 Antibody (aa508-538) LS-C329041
Rabbit Polyclonal (IgG) to Human USP2
Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

USP2 Antibody (aa71-101) LS-C326231
Rabbit Polyclonal (IgG) to Human USP2
Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00
Showing 1-25 of 69 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).