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Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.
Gene Name: | ubiquitin specific peptidase 19 |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP19, KIAA0891, Ubiquitin thioesterase 19, Ubiquitin thiolesterase 19, Deubiquitinating enzyme 19, Ubiquitin specific protease 19, ZMYND9 |
Target Sequences: | BC014934 BAA74914.1 O94966 |
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