USP17L2 / DUB3

ubiquitin specific peptidase 17-like family member 2

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.

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Products

Proteins (2)

Type

Over-Expression Lysate (1)

Recombinant (1)

Target

USP17L2 / DUB3 (2)

Publications

No (2)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (1)

Species

Human (2)

Source

293T Cells (1)

Wheat Germ Extract (1)

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Human USP17L2 / DUB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92915

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.6 kDa

Price:

20 µg/$150

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Human USP17L2 / DUB3 Protein (Recombinant GST, N-terminus) (aa431-530) - LS-G64613

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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