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USP16
ubiquitin specific peptidase 16
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
| Gene Name: | ubiquitin specific peptidase 16 |
| Family/Subfamily: | Protease , Cysteine C19 |
| Synonyms: | USP16, Deubiquitinating enzyme 16, Ubiquitin thiolesterase 16, UBP-M, Ubiquitin specific protease 16, Ubiquitin thioesterase 16 |
| Target Sequences: | NM_006447 NP_006438.1 Q9Y5T5 |
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