USP15

ubiquitin specific peptidase 15

Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

USP15 (5)

Publications

No (5)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human USP15 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67471

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.1 kDa

Price:

20 µg/$1,107

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USP15 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115392

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.1 kDa

Price:

100 µg/$710

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Human USP15 Protein (Recombinant His) - LS-G2454

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276; 20 µg/$332; 100 µg/$544; 500 µg/$1,473

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Human USP15 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79923

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.1 kDa

Price:

20 µg/$215

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Human USP15 Protein (Recombinant GST) (Full Length) - LS-G31871

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.59 kDa

Price:

10 µg/$479; 25 µg/$670

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