USP13

ubiquitin specific peptidase 13 (isopeptidase T-3)

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

USP13 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human USP13 Protein (Recombinant GST) (Full Length) - LS-G31417

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

121.44 kDa

Price:

10 µg/$479; 25 µg/$670

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Human USP13 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67258

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.1 kDa

Price:

20 µg/$1,107

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USP13 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100176

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.1 kDa

Price:

100 µg/$494

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Human USP13 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79435

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.1 kDa

Price:

20 µg/$150

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