USP10

ubiquitin specific peptidase 10

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

USP10 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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USP10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116156

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87 kDa

Price:

100 µg/$494

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Human USP10 Protein (Recombinant GST) (Full Length) - LS-G31476

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

113.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human USP10 Protein (Recombinant GST, N-terminus) (aa699-797) - LS-G60992

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human USP10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78220

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87 kDa

Price:

20 µg/$150

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