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URM1

ubiquitin related modifier 1

Acts as a sulfur carrier required for 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm5S2U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Gene Name: ubiquitin related modifier 1
Synonyms: URM1, C9orf74, RP11-339B21.4, Ubiquitin related modifier 1
Target Sequences: NM_030914 NP_112176.1 Q9BTM9

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
URM1 (4)
No (4)
His (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
URM1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
11.2 kDa
100 µg/$494
URM1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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293T Cells
Myc-DDK (Flag)
11.2 kDa
20 µg/$150
URM1 Protein - Purified recombinant protein URM1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
11.2 kDa
20 µg/$1,107
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).