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URAT1 / SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12

URAT1 / SLC22A12 is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.

Gene Name: solute carrier family 22 (organic anion/urate transporter), member 12
Family/Subfamily: Transporter , Organic cation transporter
Synonyms: SLC22A12, OATL4, RST, OAT4L, Urate transporter 1, Urate anion exchanger 1, Renal-specific transporter, URAT1
Target Sequences: NM_144585 NP_653186.2 Q96S37

Publications (1)

1
Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine. Lee SH, Lee HS, Park G, Oh SM, Oh DS. BMC complementary and alternative medicine. 2019 March;19:57. [Full Text Article] [PubMed:30871515] [PMC:PMC6419507] Related Antibodies: LS-C335533.

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
URAT1 / SLC22A12 (4)
No (4)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
URAT1 / SLC22A12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.4 kDa
20 µg/$150
URAT1 / SLC22A12 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
URAT1 / SLC22A12 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.4 kDa
100 µg/$494
URAT1 / SLC22A12 Protein - 12.5% SDS-PAGE of human SLC22A12 stained with Coomassie Blue
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Wheat Germ Extract
GST
86 kDa
2 µg/$439
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).