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UPRT encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer.
Gene Name: | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) |
Synonyms: | UPRT, FUR1, UMP pyrophosphorylase, UPP, RP11-311P8.3, UPRTase |
Target Sequences: | NM_145052 NP_659489.1 Q96BW1 |
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