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UNC13A
unc-13 homolog A (C. elegans)
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome.
| Gene Name: | unc-13 homolog A (C. elegans) |
| Synonyms: | UNC13A, KIAA1032, Munc13-1, Unc-13 homolog A (C. elegans), Protein unc-13 homolog A |
| Target Sequences: | AB028955 BAA82984.2 Q9UPW8 |
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