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ULBP3
UL16 binding protein 3
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.
| Gene Name: | UL16 binding protein 3 |
| Synonyms: | ULBP3, ALCAN-gamma, NKG2D ligand 3, NKG2DL3, RAET1N, N2DL3, UL16 binding protein 3, UL16-binding protein 3, N2DL-3 |
| Target Sequences: | NM_024518 NP_078794.1 Q9BZM4 |
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