UEV1 / UEV1A

ubiquitin-conjugating enzyme E2 variant 1

Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

UEV1 / UEV1A (6)

Publications

No (6)

Tag

6His, C-terminus (2)

GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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UEV1 / UEV1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120845

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.3 kDa

Price:

100 µg/$494

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Human UEV1 / UEV1A Protein (Recombinant GST) (Full Length) - LS-G30825

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.91 kDa

Price:

10 µg/$479; 25 µg/$670

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Human UEV1 / UEV1A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72156

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.3 kDa

Price:

20 µg/$1,107

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Human UEV1 / UEV1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91565

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.3 kDa

Price:

20 µg/$150

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Human UEV1 / UEV1A Protein (Recombinant 6His, C-terminus) (Ala2-Asn147) - LS-G138788

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.5 kDa

Price:

10 µg/$336; 50 µg/$372

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Human UEV1 / UEV1A Protein (Recombinant 6His, C-terminus) (Ala2-Asn147) - LS-G39727

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.5kD

Price:

10 µg/$248; 50 µg/$284; 500 µg/$468; 1 mg/$1,203

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