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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
Protein Family And Group
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UCP1 / UCP-1

uncoupling protein 1 (mitochondrial, proton carrier)

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

Gene Name: uncoupling protein 1 (mitochondrial, proton carrier)
Family/Subfamily: Transporter , Mitochondrial carrier
Synonyms: UCP1, Thermogenin, SLC25A7, UCP-1, UCP 1
Target Sequences: NM_021833 NP_068605.1 P25874

Viewing 1-25 of 58 items
UCP1 / UCP-1 Antibody - Anti-UCP1 / UCP-1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
UCP1 / UCP-1 Antibody - Antibody (1 ug/ml) staining of Human Adipose lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Select
Goat Polyclonal to Human UCP1 / UCP-1
Human
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
UCP1 / UCP-1 Antibody
Select
Rabbit Polyclonal to Mouse UCP1 / UCP-1
Mouse
WB
Unconjugated
100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $545.00
UCP1 / UCP-1 Antibody - UCP1 antibody Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human UCP1 / UCP-1
Mouse, Sheep, Bovine, Rat, Human
WB
Unconjugated
100µl   0.5mg/ml   $365.00
Select
Rabbit Polyclonal (IgG) to Mouse UCP1 / UCP-1
Mouse, Rat
ELISA, WB
Unconjugated
100µl   $725.00
Select
Rabbit Polyclonal (IgG) to Mouse UCP1 / UCP-1
Mouse, Rat
ELISA, WB
Unconjugated
100µl   $725.00
UCP1 / UCP-1 Antibody - IHC image of UCP1 Antibody diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal to Mouse UCP1 / UCP-1
Mouse
WB
Unconjugated
100µg   $725.00
UCP1 / UCP-1 Antibody - UCP1 Antibody (C-term) Western blot analysis in 293 cell line lysates (35 ug/lane). This demonstrates the UCP1 antibody detected the UCP1 protein (arrow).
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Rabbit Polyclonal to Human UCP1 / UCP-1
Mouse, Human
WB
Unconjugated
50µg   0.25mg/ml   $250.00
UCP1 / UCP-1 Antibody - Immunohistochemistry of paraffin-embedded human testis using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $285.00; 100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, IHC, WB
Unconjugated
100µg   $435.00
UCP1 / UCP-1 Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
UCP1 / UCP-1 Antibody - Immunofluorescence staining of UCP2 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human UCP2 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ICC, IF
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
UCP1 / UCP-1 Antibody - Immunohistochemistry of paraffin-embedded human testis using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, IHC, IHC-P
Unconjugated
50µl   $285.00; 100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Human
ELISA, IHC
Unconjugated
20µl   1.5mg/ml   $205.00; 60µl   1.5mg/ml   $235.00; 120µl   1.5mg/ml   $295.00; 200µl   1.5mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Mouse UCP1 / UCP-1
Mouse, Rat
ELISA, WB
Unconjugated
100µg   $755.00
UCP1 / UCP-1 Antibody - Western blot analysis of extracts of various cell lines, using UCP1 antibody.
Select
Rabbit Polyclonal (IgG) to Human UCP1 / UCP-1
Mouse, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
UCP1 / UCP-1 Antibody - UCP1 monoclonal antibody (M03), clone 4B7. Western blot of UCP1 expression in NIH/3T3.
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Mouse Monoclonal [clone 4B7] (IgG2a,k) to Human UCP1 / UCP-1
Mouse, Human
ELISA, WB
Unconjugated
50µg   $365.00
Select
Rabbit Polyclonal to Human UCP1 / UCP-1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
UCP1 / UCP-1 Antibody - WB of UCP1 / UCP-1 antibody. Lane 1: Rat Spleen Tissue Lysate. Lane 2: Rat Lung Tissue Lysate. Lane 3: Mouse Spleen Tissue Lysate. Lane 4: Mouse Lung Tissue Lysate. Lane 5: HEPA Cell Lysate.
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Rabbit Polyclonal to Mouse UCP1 / UCP-1
Mouse, Rat
WB
Unconjugated
100µg   0.5mg/ml   $325.00
UCP1 / UCP-1 Antibody - Western blot testing of 1) rat heart and 2) mouse heart lysate with UCP1 antibody at 0.5ug/ml. Predicted molecular weight ~33 kDa.
Select
Rabbit Polyclonal (IgG) to Mouse UCP1 / UCP-1
Mouse, Rat
WB
Unconjugated
100µg   $435.00
Select
Mouse Monoclonal (IgG2b) to Human UCP1 / UCP-1
Mouse, Human
WB
Unconjugated
100µg   $695.00

Viewing 1-25 of 58 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).