UCHL3

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

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Products

Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (11)

Target

UCHL3 (13)

Publications

No (13)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (5)

His,N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (1)

Rat (2)

Source

293T Cells (1)

E. coli (8)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

Biologically Active

Biologically active (1)

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Human UCHL3 Protein (Recombinant His,N-terminus) (aa2-230) - LS-G15806

Source:

E. coli

Tag:

His,N-terminus

Molecular Weight:

27.6 kDa

Price:

10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human UCHL3 Protein (Recombinant GST, N-terminus) (aa131-230) - LS-G60470

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human UCHL3 Protein (Recombinant GST) (Full Length) - LS-G30831

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.82 kDa

Price:

10 µg/$479; 25 µg/$670

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Human UCHL3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67256

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26 kDa

Price:

20 µg/$1,107

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Human UCHL3 Protein (Recombinant His) (Glu2-Ala230) - LS-G98006

Source:

E. coli

Tag:

His

Molecular Weight:

27 kDa

Price:

50 µg/$721

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Human UCHL3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79431

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26 kDa

Price:

20 µg/$150

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Mouse UCHL3 Protein (Recombinant His) (Glu2-Ala230) - LS-G98301

Source:

E. coli

Tag:

His

Molecular Weight:

27.5 kDa

Price:

50 µg/$721

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UCHL3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100701

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26 kDa

Price:

100 µg/$494

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Human UCHL3 Protein (Recombinant His) - LS-G1096

Source:

E. coli

Tag:

His

Biological Activity:

Biologically active

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human UCHL3 Protein (Recombinant 6His, C-terminus) (Met1-Ala230) - LS-G38721

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

27.25kD

Price:

10 µg/$304; 50 µg/$493; 500 µg/$1,585; 1 mg/$2,157

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Rat UCHL3 Protein (Recombinant His) (Glu2-Ala230) - LS-G98493

Source:

E. coli

Tag:

His

Molecular Weight:

27.5 kDa

Price:

50 µg/$721

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Human UCHL3 Protein (Recombinant 6His, C-terminus) (Met1-Ala230) - LS-G139983

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

27.3 kDa

Price:

10 µg/$325; 50 µg/$522

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Rat UCHL3 Protein (Recombinant His) (aa2-230) - LS-G15807

Source:

E. coli

Tag:

His

Molecular Weight:

27.5 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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