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UCHL1 / PGP9.5
ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase)
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
| Gene Name: | ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase) |
| Family/Subfamily: | Protease , Cysteine C12 |
| Synonyms: | UCHL1, Ubiquitin C-terminal hydrolase, PARK5, PGP9.5, PGP95, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Uch-L1, Ubiquitin carboxyl-terminal esterase L1, HEL-117, NDGOA, HEL-S-53, SPG79 |
| Target Sequences: | NM_004181 NP_004172.2 P09936 |
Publications (4)
1
Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system. Liu YA, Chen Y, Chiang AS, Peng SJ, Pasricha PJ, Tang SC. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2011 23:e446-57. (IHC)
[PubMed:21895876]
2
Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. Zhang M, Deng Y, Luo Y, Zhang S, Zou H, Cai F, Wada K, Song W. Journal of neurochemistry. 2012 120:1129-38.
[PubMed:22212137]
3
The fetal ovary exhibits temporal sensitivity to a 'real-life' mixture of environmental chemicals. Lea RG, Amezaga MR, Loup B, Mandon-Pépin B, Stefansdottir A, Filis P, Kyle C, Zhang Z, Allen C, Purdie L, Jouneau L, Cotinot C, Rhind SM, Sinclair KD, Fowler PA. Scientific reports. 2016 6:22279. (WB; Human)
[Full Text Article]
[PubMed:26931299]
[PMC:PMC4773987]
Related Antibodies: LS-B489.
☰ Filters
Products
Proteins
(18)
Type
Over-Expression Lysate
(2)
Recombinant
(16)
Target
UCHL1 / PGP9.5
(18)
Publications
No
(18)
Tag
6His, C-terminus
(2)
6His, N-terminus
(1)
GST
(1)
GST, N-terminus
(2)
His
(6)
His,N-terminus
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Human
(12)
Mouse
(3)
Rat
(2)
Source
293T Cells
(1)
E. coli
(12)
HEK 293 Cells
(2)
Wheat Germ Extract
(3)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(2)
Biologically Active
Biologically active
(1)
E. coli
6His, N-terminus
25 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
293T Cells
Myc-DDK (Flag)
24.6 kDa
20 µg/$150
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
His,N-terminus
25.6 kDa
50 µg/$649
Wheat Germ Extract
GST
50.27 kDa
10 µg/$479; 25 µg/$670
E. coli
His
28.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
Myc-DDK (Flag)
24.6 kDa
20 µg/$1,107
E. coli
His
26.2 kDa
100 µg/$661
E. coli
His
26.2 kDa
50 µg/$854
HEK 293 Cells
Myc-DDK (Flag)
24.6 kDa
100 µg/$494
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.9 kDa
10 µg/$336; 50 µg/$400
E. coli
None
Biologically active
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.89kD
10 µg/$248; 50 µg/$313; 500 µg/$1,010; 1 mg/$1,329
E. coli
His
25.9 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
E. coli
His
26.9 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
E. coli
His-T7
28.2 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
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